The invention discloses a ceramic material with bioactivity as well as a preparation method and application thereof. The chemical formula of the ceramic material with bioactivity is Ca10Si3O15F2. A calcium fluosilicate biological ceramic material prepared with the method can improve the toughness of the ceramic material; meanwhile, by the introduction of fluorine, sedimentation of hydroxyapatite on the surface of biological ceramic in a mineralization process can be accelerated; as the mineralization time goes by, the thickness of the hydroxyapatite is increased, the hydroxyapatite cannot be degraded, and external acid attack can also be resisted. The preparation method is simple, extremely low in defective percentage, stable in product performance and high in repetitiveness; no waste gas is discharged, and the preparation method is environment-friendly; the prepared ceramic material is high in bioactivity, excellent in toughness and high in intensity, and can be used as a filling material for bone repair, bone defect repair and tooth repair.