The invention discloses a preparation method of an artificial mud shale core for a pressure transmission experiment. According to the method, a geological broken core or a collapsed stratum block collected on site is treated and then arranged in the center of epoxy resin in a covered manner, an experimental core is prepared, physical and chemical properties of mud shale are reserved to the greatest extent, an interaction process of a drilling liquid and the mud shale can be simulated really, the artificial mud shale core can be resistant to the high temperature of 150 DEG C, and an evaluation test of a plugging effect of the drilling liquid on the mud shale can be implemented on a pressure transmission tester.