The invention relates to the technical field of mobile communications, and discloses a method and device for calibrating a mobile terminal. The method comprises the following steps: determining a support mode frequency band number and support frequency band start and stop frequency points of the mobile terminal through a support mode frequency band number index table and a support frequency band start and stop frequency point index table; acquiring a control codeword storage location index table and a calibration result storage location index table needed for production and calibration according to the support mode frequency band number and the support frequency band start and stop frequency points of the mobile terminal; and acquiring the control codeword storage location and the calibration result storage location of the mobile terminal according to the control codeword storage location index table and the calibration result storage location index table. Since the control codeword storage location and the calibration result storage location are under different mode states, spatial multiplexing mode management is adopted, so that the space waste of the mobile terminal is effectively reduced and meanwhile the system compatibility of the mobile terminal is improved.