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发明公开
CN106913862A 蛋白TIF1‑β及其多肽在制备治疗与预防癌症的药物中的应用 有权 许可

蛋白TIF1‑β及其多肽在制备治疗与预防癌症的药物中的应用
摘要：
本发明提供蛋白TIF1‑β及其多肽在制备治疗与预防癌症的药物中的应用，所述癌症为乳腺癌及肝癌。利用本发明提供的活性成分为蛋白TIF1‑β及其多肽的药物(疫苗)免疫数周后，可引发机体产生特异的免疫反应，清除体内肿瘤干细胞和/或肿瘤休眠细胞，以及癌变的细胞，从而达到预防和治疗癌症的目的。本发明可作为肿瘤预防性疫苗，用于自体或异体肿瘤防治，降低健康人群中癌症的发生率，也可作为肿瘤治疗性疫苗，患者术后即时施治能有效防转移防复发，或作为化学疗法的辅助治疗。本发明提供的蛋白TIF1‑β及其多肽也可以用于异体肿瘤的免疫防治。
摘要（英）：

The invention provides protein TIF1-beta and an application of polypeptide of the protein TIF1-beta in preparation of a medicine for treating and preventing cancer, wherein the cancer is breast cancer and liver cancer. The medicine (vaccine) having the provided active component of the protein TIF1-beta and its polypeptide is used for immunization for several weeks, specific immunization reaction is generated for the body, tumour stem cell and/or tumour resting cell in the body can be removed, cancerous cells can be removed, so that the purpose of preventing and treating cancer can be achieved. The protein TIF1-beta can be used as tumour prophylactic vaccine and used for preventing and treating autologous or variant tumour, reduces incidence rate of cancer in health population, can be taken as tumour therapeutic vaccine, can effectively prevent transfer and recurrence by instant application after operation, or can be used as an auxiliary treatment of chemotherapy. The protein TIF1-beta and its polypeptide also can be used for immunization control of variant tumour.

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