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发明授权
CN106913885B 一种磁性纳米粒子及其制备方法和应用 有权

一种磁性纳米粒子及其制备方法和应用
摘要：
本发明涉及一种磁性纳米粒子及其制备方法和应用。具体地，所述磁性纳米粒子具有下组特征：1)所述磁性纳米粒子为铁氧体；2)所述磁性纳米粒子的粒径为0.1‑30nm；3)所述磁性纳米粒子的弛豫率r1≥1.2mM‑1s‑1；4)所述磁性纳米粒子的驰豫率比r2/r1≤3.5且r2/r1≥1.05；5)0.5mM所述磁性纳米粒子的T1加权信号强度≥70。本发明还公开了所述磁性纳米粒子的制备方法和应用。将所述磁性纳米粒子应用于磁共振成像中可获得一种成像性能显著优异、磁敏感性高且T1信号丰富的优质MRI造影剂，可提高其对肿瘤、心脑血管等重大疾病的发现与检出，从而显著降低医学检测和治疗成本。
摘要（英）：

The invention relates to a magnetic nanoparticle, and a preparation method and application thereof. Specifically, the magnetic nanoparticle has the characteristics that 1) the magnetic nanoparticle is ferrite; 2) the magnetic nanoparticle has a particle size of 0.1 to 30 nm; 3) the relaxation rate r1 of the magnetic nanoparticle is no less than 1.2 m/M/s; 4) a ratio of a relaxation rate r2 to the relaxation rate r1 of the magnetic nanoparticle is no more than 3.5 and no less than 1.05; and 5) the T1 weighted signal intensity of 0.5mM of the magnetic nanoparticle is no less than 70. The invention also discloses the preparation method and application of the magnetic nanoparticle. When the magnetic nanoparticle is applied to magnetic resonance imaging, a high-quality MRI contrast agent with substantial and excellent imaging performance, high magnetosensitivity and rich T1 signals can be obtained, and the MRI contrast agent is improved in discovery and detection of tumors, cardio-cerebrovascular diseases and other serious diseases, so medical detection and treatment cost can be substantially lowered.

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