Disclosed in the present invention is a quantum dot synthesis device, comprising: sequentially connected, a precursor reaction area, a core reaction area, a core/shell reaction area for a core/shell reaction, and a storage container. Each of the described reaction areas comprises at least one spiral reaction tube. An inner wall of the spiral reaction tube is provided with a passing groove having a direction opposite to the spiral direction and allowing reactants injected into the reaction tube to generate a bubbling effect due to friction. A front segment of the each reaction area is coated with a heating zone. A rear segment of the each reaction area is coated with a cooling zone. A plurality of injection ports are provided at a front end of the each reaction area. A plurality of seston outlets are provided respectively at a rear end of the core reaction area and a rear end of the core/shell reaction area. The front end of each reaction area is connected with a pressurizing device. A quantum dot synthesis method is further disclosed in the present invention. The present invention improves the stability of quantum dots and the size uniformity of particles, and ensures that the quantum dots have no defects, so that the quantum efficiency is maximized, and luminous efficiency and sharpness are improved.