The invention discloses a small current grounding comprehensive wire selection method based on electric quantity and non-electric quantity. The method includes the following steps: if a bus voltage abnormal alert is started, acquiring a zero-sequence current of a voltage abnormal bus associated line, determining whether it is established that a certain line has the largest zero-sequence current and the largest zero-sequence current is the sum of zero-sequence currents of the other lines, and if it is established, the line has a grounding breakdown; and if it is not established, acquiring the non-electric quantity information of the voltage abnormal bus associated line, using the method of weighting to compute breakdown probability of each line, successively cutting and removing corresponding lines according to the sequence of the breakdown probability, if the bus voltage returns to normal, then determining that the line has a grounding breakdown. The method can schedule a main station end and accurately identify lines with grounding breakdowns, enables closed-loop processing through remote controlling in a fast and efficient manner, increases the accuracy of small current grounding and switching off, shortens time for processing breakdowns, reduces the work load of scheduling workers, and effectively ensures reliability of grid power supply.