The invention relates to a catalyst for reducing the content of NOX in FCC smoke and a preparation method of the catalyst. The catalyst consists of an acidic inorganic oxide carrier and layered metallic oxide, wherein the acidic inorganic oxide carrier contains aluminum oxide and/or silicon oxide; the inner layer of the layered metallic oxide comprises rare-earth oxide M and group IVB metallic oxide N; the outer layer of the layered metallic oxide comprises transition metallic oxide X except the rare-earth oxide and the group IVB metallic oxide. On the basis of 100% of mass of the catalyst, the rare-earth oxide M accounts for 0.1-12.0%, the group IVB metallic oxide N accounts for 0.1-15%, the transition metallic oxide X except the rare-earth oxide and the group IVB metallic oxide accounts for 0.1-12.0%, and the balance is the acidic inorganic oxide carrier contains the aluminum oxide and/or the silicon oxide. The disclosed catalyst has good denitration efficiency, and is suitable for an oxygen-rich regeneration environment and an oxygen-poor regeneration environment.