The invention discloses a 1,4-pentadiene-3-ketone derivative containing coumarin. The 1,4-pentadiene-3-ketone derivative containing the coumarin is characterized in that a general formula is shown as follows: (shown in the description), wherein R1 is phenyl, substituted phenyl or substituted aromatic heterocyclic group; R2 is one or more of hydrogen atoms, methoxyl, nitryl, methyl, trifluoromethyl or halogen atoms contained on site 5, 6, 7 or 8 of the coumarin structure. The compound has excellent inhibition activity for stomach cancer SGC7901 cells and liver cancer hepG2 cells, has relatively high antitumor activity and can be used as a potential antitumor drug.