The invention belongs to the field of preparation of organic-inorganic hybridized materials and in particular discloses a preparation method of an inorganic nanoparticle@PAM hybridized material. The preparation method comprises the following steps: firstly, preparing peroxidized inorganic nanoparticles; then adding acrylamide and ferrous chloride to form a redox system; and then performing a reaction to obtain the inorganic nanoparticle@PAM hybridized material. According to the reaction system, in a condition of low pressure heating, other initiators are not needed to be added or bonded, and the inorganic nanoparticles can directly initialize polymerization on the surface of an organic monomer; and the risk, caused by odors of drugs, brought to test personnel in the preparation process is avoided, and the preparation process is also simplified. By applying a reaction mechanism of the redox system, the operating flow is simpler. The method is mainly characterized in that the preparation process is simple and the initializing mechanism is novel.