The invention relates to an anti-cavitation high-lift centrifugal pump impeller. The brand new anti-cavitation high-lift centrifugal pump impeller is disclosed in order to solve the problem that the lift of a centrifugal pump is reduced due to the fact that the pressure of fluid in an impeller is rapidly reduced along with the increase of the cavitation intensity in the operation process of the centrifugal pump. The anti-cavitation high-lift centrifugal pump impeller comprises blades, a cover plate and bosses. Each boss is fixedly connected with the corresponding blade and located on one side of the working surface of the blade. According to the anti-cavitation high-lift centrifugal pump impeller disclosed by the invention, the structure is simple; machining is convenient; and in addition, the boss structures are arranged on the working surfaces of the blades, so that an improvement effect is achieved on a low-pressure area and the adverse pressure gradient in an impeller runner, then an inhibiting effect is achieved on the void volume produced when cavitation occurs to a centrifugal pump, and thus the purposes of increasing the lift value of the centrifugal pump under the cavitation state and expanding the efficient operation area of the centrifugal pump under the cavitation state are achieved.