The invention relates to a comprehensive prevention and treatment method for Corythucha ciliata. The comprehensive prevention and treatment method comprises the following steps: (1) adding river sand, gravels or biological carbon into soil; (2) applying a bamboo-vinegar liquid or a humic acid containing fertilizer into the soil; (3) applying plant immune and yield-increase protein into the soil in the wintering period of the Corythucha ciliata; (4) carrying out root-irrigating to Platanus acerifolia by adopting a systemic pesticide in the occurrence period of the Corythucha ciliata; (5) carrying out whitewashing to the Platanus acerifolia by adopting a whitewashing agent; and (6) planting plants between the Platanus acerifolia. The method provided by the invention solves the following problems for the Corythucha ciliata in the prior art: serious waste of a pesticide is caused due to high-altitude pesticide spraying, and threats to environmental safety and pedestrian health are caused due to loss of the pesticide to the environment; the pesticide has short effective duration and may cause severe damage to a tree body; meanwhile, holing is time-consuming and labor-consuming, and has low efficiency; and a conventional prevention and control method is simple, etc.