The invention discloses an ear-nose-throat drug spraying device. The ear-nose-throat drug spraying device comprises a device frame, wherein a first through pipe is fixedly connected with the top of the device frame; a rotary shaft is arranged at one end, far away from the device frame, of the first through pipe; the first through pipe is rotatably connected with a second through pipe through a rotary shaft; the second through pipe and the device frame are connected through a turn buckle; a mounting groove is formed in the device frame; an airbag is arranged in the mounting groove; one end of the airbag penetrates through an inner side wall of the mounting groove and extends into the first through pipe; one extending end of the airbag is fixedly connected with a hose; one end, far away from the airbag, of the hose penetrates through an inner side wall of the first through pipe and extends into the second through pipe; a spraying pipe is fixedly connected with one extending end of the hose. According to the ear-nose-throat drug spraying device disclosed by the invention, the angle of a spraying nozzle can be freely adjusted according to body postures of a patient; meanwhile, drug liquid can be supplemented into a drug liquid bottle through a liquid feeding guide pipe and great convenience is brought to a user.