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发明授权
CN106947763B 可雾化吸入的抗流感病毒感染的siRNA及其应用 有权

可雾化吸入的抗流感病毒感染的siRNA及其应用
摘要：
本发明公开了可雾化吸入的抗流感病毒感染的siRNA及其应用。该siRNA是名称为siPB2‑1、siPB2‑2、siPB1‑2或siNS‑1的双链RNA分子；siPB2‑1的一条链序列为序列表中SEQ ID No.1；siPB2‑2的一条链序列为序列表中SEQ ID No.3；siPB1‑2的一条链序列为序列表中SEQ ID No.5；siNS‑1的一条链序列为序列表中SEQ ID No.7。该siRNA的EC50和小鼠体内实验的用量小于文献报道，作为抗流感病毒药物将大大降低使用成本，不仅针对A型流感病毒，对于B型流感病毒同样具有抑制作用。
摘要（英）：

The present invention discloses anti-influenza virus infection siRNA capable of being subjected to atomizing inhalation, and applications thereof. According to the present invention, the siRNA is a double-stranded RNA molecule named siPB2-1, siPB2-2, siPB1-2 or siNS-1, the sequence of one chain of the siPB2-1 is represented by SEQ ID No.1 in the sequence table, the sequence of one chain of the siPB2-2 is represented by SEQ ID No3. in the sequence table, the sequence of one chain of the siPB1-2 is represented by SEQ ID No.5 in the sequence table, and the sequence of one chain of the siNS-1 is represented by SEQ ID No.7 in the sequence table; and the EC50 and the consumption in the in vivo mouse experiment of the siRNA are lower than the the EC50 and the consumption reported in the literature, such that the use cost can be substantially reduced by using the anti-influenza virus infection siRNA as the anti-influenza virus drug, and the inhibition effects can be provided for influenza viruses type A and influenza viruses type B.

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