The invention discloses an isolation switch control device, and relates to the technical field of power transmission and distribution equipment of a power system. The isolation switch control device comprises an operating mechanism body, wherein the operating mechanism body comprises a front installation plate and a rear installation plate, an isolation grounding output shaft and a groove plate are arranged on the rear installation plate, a lead rod and a nut are arranged at a top end of the rear installation plate, an isolation operating shaft is arranged at one end of the lead rod, a bevel gear and a clutch sleeve are arranged on the isolation operating shaft, a grounding shaft is arranged at the bottom of the rear installation plate, a swinging plate is arranged on the grounding plate, a grounding spring is arranged at a tail end of the swinging plate, a large baffle piece and a small baffle piece are arranged on the front installation plate, a tongue sheet is arranged on the large baffle piece, a grounding operation shaft is arranged on the small baffle piece, an interlocking device is arranged at the bottom of the small baffle piece, and a top rod is arranged at the bottom of the interlocking device. The mechanism structure comprises three parts of isolation operating, grounding operating and the interlocking device, can be installed on a switch cabinet when used as a module, is directly connected with an isolation switch and drives the isolation switch to do isolation closing and breaking actions and grounding closing and breaking actions.