The invention belongs to the field of glass production and particularly relates to a nano-scale microcrystalline glass used in the dental department and a production method thereof. The nano-scale microcrystalline glass contains 54%-61.3% of SiO2, 5%-23% of Al2O3, 0%-4% of Na2O, 1.5%-4% of K2O, 3%-20% of CaO, 0.4%-7% of P2O5, 1%-4% of ZnO, 4%-6% of ZrO2, 1%-2.7% of NaF and 1%-3% of TiO2 according to the chemical composition of a final product. The prepared microcrystalline glass is relatively centralized in grain size, only one crystalline phase crystalline phase exists, and the bending strength and elastic modulus of the microcrystalline glass meet the performance requirements of human teeth. In addition, due to the small grain size, the visible light region transmittance rate is up to 91%, the ultraviolet cut-off rate is up to 100%, the nano-scale microcrystalline glass is especially suitable for alternative materials used on the enamel aspect in the dental department, the preparation process is simple, the technology is mature, and operation is easy.