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发明授权
CN106970222B 用于血清中肝癌标志物联合检测的抗体及试剂盒 有权

  • 专利标题： 用于血清中肝癌标志物联合检测的抗体及试剂盒
  • 申请号： CN201710194782.0
    申请日： 2017-03-28
  • 公开(公告)号： CN106970222B
    公开(公告)日： 2019-08-16
  • 发明人: 马杰 , 吴云
  • 申请人： 马杰
  • 申请人地址： 北京市朝阳区望京科技创业园505A
  • 专利权人： 马杰
  • 当前专利权人： 马杰
  • 当前专利权人地址： 北京市朝阳区望京科技创业园505A
  • 代理机构： 北京海虹嘉诚知识产权代理有限公司
  • 代理商 吴泳历
  • 主分类号： C12N5/12
  • IPC分类号： C12N5/12
用于血清中肝癌标志物联合检测的抗体及试剂盒
摘要：
本发明涉及血清抗原检测技术，具体涉及一种用于血清中肝癌标志物联合检测的抗体及试剂盒。提供用于血清中肝癌标志物联合检测的抗体组合物，包括抗AFP的抗体对、抗GP73的抗体对、抗VEGF的抗体对、抗CD147的抗体对、抗AFU的抗体对中的至少两对，所述抗体对由作为包被抗体的第一抗体和作为检测抗体的第二抗体组成。该抗体组合物特异性强，同时检测AFP，GP73，AFU，VEGF，CD147时相互不受干扰；灵敏度高，检测AFP，GP73，AFU，VEGF的灵敏度均可达到250pg/ml，检测CD147的灵敏度可达到64pg/ml，能够用于血清中肝癌标志物的准确定量。
摘要（英）：

The invention relates to serum antigen detection technology, in particular to an antibody for joint detection of a hepatoma marker in serum and a kit. An antibody composition for the joint detection of the hepatoma marker in the serum is provided, including at least two of an antibody pair against AFP, an antibody pair against GP73, an antibody pair against VEGF, an antibody pair against CD147 and an antibody pair against AFU, and the antibody pairs consist of first antibodies functioning as coating antibodies and second antibodies functioning as detection antibodies. The antibody composition is strong in specificity, and the AFP, the GP73, the AFU, the VEGF and the CD147 do not interfere with one another when detected simultaneously; the sensitivity is high, the sensitivity of the AFP, the GP73, the AFU and the VEGF can be up to 250pg/ml through detection, the sensitivity of the CD147 can be up to 64pg/ml through detection, and the antibody provided by the invention can be used for accurately quantifying the hepatoma marker in the serum.

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