The invention discloses a detachable large-section beam bearer system and a manufacturing method thereof. The detachable large-section beam bearer system comprises a large-section beam, bearers and connecting pieces. Each of the two sides of the large-section beam is provided with one bearer, and the bearers are detachably connected with the large-section beam through the connecting pieces; the two bearers are of a symmetrical structure, each bearer comprises two layers of horizontal steel plates arranged side by side, a penetrating preformed port is arranged in the two layers of horizontal steel plates in order to fix a steel pipe connected with the horizontal steel plates, the steel pipe has an additional length relative to the upper layer horizontal steel plate, joints of the bearers and the large-section beam are provided with connection surfaces which are vertical to the horizontal steel plates, and each connection surface is provided with a preformed hole matched with the corresponding connecting piece. The problem that in the model test of the civil engineering field and the industrial plant production process, the large-section beam bearers need to be dismounted and moved conveniently is solved, and the detachable large-section beam bearer system is advantaged by being large in design carrying capacity, light in self weight, simple to manufacture, convenient to dismount and move, and good in fixation effect.