The invention discloses a production technology of compound sodium gualenate gargle. The production technology comprises the steps of preparing a solution I: heating purified water, then adding non-crystalline sorbitol, sodium benzoate and cetylpyridinium chloride into the heated purified water, and stirring for 20min; preparing a solution II: dissolving sodium gualenate by using ethanol to obtain the solution II; preparing a solution III: heating RH40 hydrogenated castor oil and propylene glycol until being molten, adding spearmint essence, and evenly stirring to obtain the solution III; adding the solution II and the solution III into the solution I, stirring for 10min to obtain a semi-finished product, taking samples for laboratory test to obtain a cetylpyridinium chloride semi-finished product, and canning the semi-finished product when the semi-finished product is qualified; when the cetylpyridinium chloride is insufficient, adding the cetylpyridinium chloride, taking samples for detection until the semi-finished product is qualified, and starting to fill; after the finished product is tested to be qualified, enabling the finished product to be put in storage, and discarding the unqualified products.