The invention provides an azo disperse dye compound as well as a synthesis method and dyeing application thereof. The disperse dye compound is shown as a general formula (1) as follows: the general formula (1) is shown in the description, wherein D, R1 to R4 and n are defined as the description. The azo disperse dye compound provided by the invention and auxiliary agents can form a disperse dye according to a certain ratio; the disperse dye has a good deep dyeing property, wide pH (Potential of Hydrogen) tolerance and good various color fastnesses. The azo disperse dye has no toxin and no carcinogenicity or allergenicity, is safe and environment-friendly, has less emission of three wastes, a simple synthesis process and a low construction price, and is suitable for requirements of market development and industrial production.