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发明授权
CN106983715B pH敏感的大内径多壁碳纳米管双重载药体系及制备方法 有权

pH敏感的大内径多壁碳纳米管双重载药体系及制备方法
摘要：
本发明公开了一种pH敏感的大内径多壁碳纳米管双重载药体系及制备方法，方法为：(1)大内径多壁碳纳米管加热处理；(2)酸处理；(3)氧化(4)过滤干燥得到固体；(5)制备含顺铂悬浊液2；(6)制备CDDP@O‑LID‑MWCNTs‑PEG；(7)制备CDDP@O‑LID‑MWCNTs‑PEG‑FA，(8)制备简写为CDDP@O‑LID‑MWCNTs‑PEG‑FA‑DOX的pH敏感的大内径多壁碳纳米管双重载药体系；本发明的体系，具有内部容量高、外表面积大的优势，提高整体载药量。在碳纳米管表面形成聚乙二醇‑叶酸‑阿霉素三级封堵结构，实现顺铂和阿霉素的pH敏感性释放。
摘要（英）：

The invention discloses a pH-sensitive large-inner-diameter multiwalled carbon nanotube dual drug loading system (CDDP@O-LID-MWCNTs-PEG-FA-DOX for short), and a preparation method thereof. The preparation method comprises following steps: 1, heating of large-inner-diameter multiwalled carbon nanotube; 2, acid treatment; 3, oxidation; 4, filtering, drying, and obtaining of an obtained solid substance; 5, preparing of a cis-platinum-containing suspending liquid; 6, preparing of CDDP@O-LID-MWCNTs-PEG; 7, preparing of CDDP@O-LID-MWCNTs-PEG-FA; and 8, preparing of the CDDP@O-LID-MWCNTs-PEG-FA-DOX. The CDDP@O-LID-MWCNTs-PEG-FA-DOX is large in internal capacity and the external surface area, so that total drug loading capacity is increased; a polyethylene glycol-folic acid-doxorubicin tertiary structure blocking structure is formed on the surface of carbon nanotube, so that pH sensitive release of cis-platinum and doxorubicin is realized.

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