The invention provides a self-powered pressure sensor possessing a high integration degree. The pressure sensor comprises a packaging shell. A cylinder of a vertical through hole is arranged in the packaging shell. The cylinder is mainly formed by a pressure sensing unit and a piezoelectric energy harvester unit which are stacked up and down. A non-polarized isolation layer is arranged between the pressure sensing unit and the piezoelectric energy harvester unit. An energy management module and a signal processing module are arranged in the vertical through hole. An output electrode of the piezoelectric energy harvester unit is electrically connected to an input terminal of the energy management module. An output electrode of the pressure sensing unit is electrically connected to an input terminal of the signal processing module. An output terminal of the energy management module is electrically connected to a power supply terminal of the signal processing module. The self-powered pressure sensor possessing the high integration degree can directly output a digital signal, can work autonomously, does not bring any burden for an external circuit and is suitable for the pressure sensing field.