The invention relates to the field of leather care, in particular to a freezing-tolerant solubilizing type leather degreasing agent. The freezing-tolerant solubilizing type leather degreasing agent is prepared from, by mass, 1%-25% of anionic surfactant, 3%-80% of non-ionic surfactant, 0.5%-8% of electrolyte and 10%-85% of water. A preparation method comprises the steps that the anionic surfactant, the non-ionic surfactant and the water are stirred to be uniform at 40 DEG C to 60 DEG C, the electrolyte is added at the same stirring speed and temperature, all the materials are mixed to be uniform and cooled to 30 DEG C, and then the product is obtained. According to the degreasing agent, fatty acid methyl ester ethoxylate is adopted as the main raw material and supplemented by the anionic surfactant for enhancing the synergetic effect, the product has a high capacity for solubilizing grease and is excellent in penetrating performance, high in degreasing rate and good in raw material biodegradability, and the freezing-tolerant solubilizing type leather degreasing agent is still a transparent flowing liquid at -10 DEG C and can serve as a specialized leather degreasing agent.