The invention relates to lucid ganoderma bud health-preserving wine and a preparation method thereof. The lucid ganoderma bud health-preserving wine consists of lucid ganoderma buds, sea-buckthorn, raspberry, cordyceps flower, dendrobe, mulberry and Baijiu. The preparation method comprises the following steps: drying and pulverizing the lucid ganoderma buds, the sea-buckthorn, the raspberry, the cordyceps flower, the dendrobe and the mulberry, putting the powder into a filtering bag of 100 to 150 meshes, putting the filtering bag into distilled water, performing extraction by a traditional Chinese medicine extracting machine, taking the liquid and putting the liquid into a filtering bag of 200 to 300 meshes, putting the filtering bag into a wine jar filled with the Baijiu, soaking, filtering and bottling to obtain the lucid ganoderma bud health-preserving wine. The lucid ganoderma bud health-preserving wine and the preparation method thereof have the following advantages: the immunological function is enhanced and chronic disease rehabilitation is promoted; the lucid ganoderma bud health-preserving wine has the protective effect on myocardial ischemia and can be widely applied to treatment and prevention of coronary heart disease and stenocardia; the lucid ganoderma bud health-preserving wine can reduce cholesterol, lipoprotein and triglyceride, can also prevent formation of atherosclerotic plaques, and has good effect of preventing and treating various kinds of stroke.