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发明公开
CN107022627A KPNA2基因的应用和抑制KPNA2基因表达的siRNA的应用 有权

KPNA2基因的应用和抑制KPNA2基因表达的siRNA的应用
摘要：
本发明提供了一种KPNA2基因的应用和抑制KPNA2基因表达的siRNA的应用，涉及医药基因工程的技术领域。本发明提供的KPNA2基因作为大肠癌生物标记物的应用，能够有效指导大肠癌的临床分期，也能够准确地判断大肠癌患者的预后。本发明提供的能够抑制KPNA2基因表达的siRNA，能够有效地抑制大肠癌细胞的增值和迁移。本发明还提供了上述siRNA在制备KPNA2基因沉默型大肠癌细胞系的应用，该细胞系可用于探究KPNA2与大肠癌的相关性及其机理，为深入研究KPNA2与大肠癌发生、发展的可能机制提供一种可靠的研究基础，从而给大肠癌的靶向治疗提供有效的治疗靶点。
摘要（英）：

The invention provides application of a KPNA2 (karyopherin alpha 2) gene and application of siRNA (small interfering ribonucleic acid) for inhibiting expression of the KPNA2 gene, and relates to the technical field of medicine gene engineering. The application of the KPNA2 gene as a colorectal cancer biomarker provided by the invention can be used for effectively instructing the clinical stages of the colorectal cancer, and accurately judging the prognosis of a colorectal cancer patient. The siRNA for inhibiting the expression of the KPNA2 gene can effectively inhibit the proliferation and transfer of colorectal cancer cells. The invention also provides application of the siRNA in preparing a KPNA2 gene silent colorectal cancer cell line. The cell line can be used for studying the correlation and mechanism between KPNA2 and the colorectal cancer, and providing a reliable study foundation for deeply studying the possible mechanism of generation and development between the KPNA2 and the colorectal cancer, thereby providing an effective therapeutic target for the target therapy of the colorectal cancer.

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