The invention discloses a frame wallboard structure system which comprises frame columns, frame beams and prefabricated wallboards. The frame columns are hinged to the frame beams. The prefabricated wallboard has the capacity of bearing vertical load and the capacity of resisting lateral force. The prefabricated wallboards are distributed in the longitudinal direction and transverse direction of the frame wallboard structure. At least one longitudinally-arranged prefabricated wallboard and at least one horizontally-arranged prefabricated wallboard are connected, and the frame columns and/or the frame beams are reliably connected with the prefabricated wallboards. According to the technical scheme, a pure dry method connection way is adopted, the frame beams and the frame columns are hinged in a dry mode, and the prefabricated wallboards and a frame are in dry connection. Construction can be continuous without stop, the construction speed is greatly increased, the construction period is shortened, the prefabricated wallboards capable of bearing vertical load and resisting lateral force are introduced into the frame structure, and the frame wallboard structure system is formed. Due to the fact that prefabricated wallboards are large in horizontal lateral force resistance rigidity, horizontal earthquake force is borne by the prefabricated wallboards, the frame structure bears the vertical load, and the whole stability of a building meets requirements.