The invention discloses a multi-spindle processing center with a rotary table. The multi-spindle processing center comprises a machine tool base, a machine tool rack which moves in the Y direction on the machine tool base, a spindle box base mounted on the upper part of the machine tool rack and a multi-spindle box which can move in the Z direction on the spindle box base, wherein the rotary table which can rotate around a Z axis is further arranged on the side, at which the multi-spindle box is located, of the machine tool base; a plurality of workpiece clamps which are linearly arranged in a spaced mode are separately arranged at the inner side and the outer side in the Y direction of the rotary table; a plurality of processing spindles which are arranged in the form of a matrix are arranged in the multi-spindle box; and number and spacing of each row of processing spindles in the multi-spindle box correspond to workpiece clamps which are arranged in rows. The multi-spindle processing center with the rotary table disclosed by the invention performs displacement control in a multi-station processing process of the multi-spindle box by moving the machine tool rack in the Y direction and moving the multi-spindle box in the Z direction; stroke displacement in a station transfer process is movement in a plane perpendicular to the X direction, so that integral design width of the multi-spindle processing center is effectively reduced; and in a site space with limited width, work of more multi-spindle processing centers can be convenient, so that the site utilization rate is favorably increased. The multi-spindle processing center is used for the machine tool processing field.