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发明公开
CN107033089A 一种α‑酮苯丙氨酸钙的制备方法 有权

一种α‑酮苯丙氨酸钙的制备方法
摘要：
本发明提供一种α‑酮苯丙氨酸钙的制备方法，本发明以甘氨酸、强碱和有机醇为催化剂，乙内酰脲和苯甲醛为原料，采用有机碱和有机醇催化环合反应得到亚苄基海因；亚苄基海因在氢氧化钠碱液中开环水解反应得到α‑酮基‑β‑甲基戊酸钠，通过新型隔板隔膜压滤机压滤得到高纯度α‑酮基‑β‑甲基戊酸钠；高纯度的α‑酮基‑β‑甲基戊酸钠与等比例醋酸钙反应得α‑酮苯丙氨酸钙。本发明制备α‑酮苯丙氨酸钙产品采用常见的有机碱和有机醇催化环合反应，产品纯度高，摩尔收率达99%，有机碱和有机醇可循环套用10批次，无废水产生。
摘要（英）：

The invention provides a method for preparing alpha-ketophenylalanine calcium. The method includes carrying out organic alkali and organic alcohol catalytic cyclization reaction on hydantoin and benzaldehyde by the aid of glycine, strong alkali and organic alcohol obtain benzalhydantoin; carrying out ring-opening hydrolysis reaction on the benzalhydantoin in sodium hydroxide alkali liquor to obtain alpha-keto-beta-methyl sodium valerate and carrying out filter-press by the aid of novel partition plate and membrane filter presses to obtain high-purity alpha-keto-beta-methyl sodium valerate; carrying out reaction on the high-purity alpha-keto-beta-methyl sodium valerate and calcium acetate with the equal proportion to obtain the alpha-ketophenylalanine calcium. The glycine, the strong alkali and the organic alcohol are used as catalysts, and the hydantoin and the benzaldehyde are used as raw materials. The method has the advantages that the common organic alkali and organic alcohol catalytic cyclization reaction is carried out to prepare alpha-ketophenylalanine calcium products, the products are high in purity, the molar yield can reach 99%, organic alkali and the organic alcohol can be recycled by 10 batches, and wastewater can be prevented.

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