The invention provides a method of fabrication of microalgae lipid. The method comprises the steps that admixture solvent of algae sludge of 3%-95% aquatic content, low polar solvent and low level of alcohol solvent and grinding balls of 1-5 millimeter in diameter are joined in a reactor, the reactor is sealed, the reactivity system is warmed to 30-70 DEG C, then stirred for 0.5-3 hours at the revolving rate of 200-450 rpm; the reactor is cooled down to workshop temperature, after the solid-liquid separation of reactant raw materials, component solvent in the liquid phase produce is removed, and microalgae lipid is obtained, after the continued separation of solid-liquid phase algal dregs, protein-rich algae dregs is obtained. By the method of fabrication of microalgae lipid, the dilapidation of wall and the drawing of microalgae are combined into one, the drawing efficiency of the lipid is increased and the process circuit is simplified by the condition of defense of the quality of microalgae cellular content, in the process of dilapidation of wall and drawing, a lower warming temperature is adopted, the drawing time of lipid is cut down, the oxidization of the lipid in the drawing process and the denaturation of protein of algae dregs due to over high temperature are prevented, the yield of protein is increased, and at the same time the quality of the drawn lipid is ensured.