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发明公开
CN107034264A 一种获得降糖药物的方法及降糖药物 无效 - 驳回

一种获得降糖药物的方法及降糖药物
摘要：
本发明公开了一种获得降糖药物的方法及降糖药物，涉及医疗卫生领域，本发明主要通过抑制炎症使早期INS‑1胰岛β细胞系以及啮齿类实验动物的胰岛素分泌能力及胰岛素抵抗能力改善来实现血糖的降低，具体的是使用含有p38 MAPK抑制剂SB203580成分的药物实现，本发明提供的降糖药物可以制备用于调理、延缓和/或治疗糖尿病的药物或保健品中的未来应用，p38 MAPK抑制剂SB203580可显著改善糖尿病者胰岛β细胞的胰岛素分泌能力和改善胰岛素抵抗、降低糖尿病者的血糖水平，通过抑制炎症，延缓和改善糖尿病的发展，在糖尿病治疗、调理中具有极高的应用前景。
摘要（英）：

The invention discloses a method for acquisition of a sugar-reducing medicine and the sugar-reducing medicine, and relates to the technical field of the medical treatment and public health. The method includes steps of through inhibiting inflammation, improving the insulin secretion capacity and the insulin resistance capacity of an early-stage INS-1 pancreas islet Beta cell line and a rodent experimental animal, and realizing the reduction of blood sugar, specifically using a pharmaceutical containing a p38 MAPK inhibitor ingredient SB203580 to realize. The provided sugar-reducing medicine is capable of preparing a pharmaceutical for nursing, delaying and/or treating diabetes or future application in a health care product. The p38 MAPK inhibitor SB203580 is capable of remarkably improving the insulin secretion capacity and the insulin resistance capacity of diabetes patient pancreas islet Beta cells, reducing the blood sugar level of the diabetes patient, and delaying and improving the development of the diabetes through inhibiting the inflammation, and has extensive application prospect in the treatment and nursing of the diabetes.

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