The invention discloses a method of switching controlling of an enthalpy difference laboratory temperature based on fuzzy control and PID control. The method comprises: (1) a plurality of temperature sensors are selected and the selected temperature sensors are arranged at an outdoor side, an average temperature of the outdoor side is marked as x2 and a power of a heater is marked as y, and according to a temperature error e between an expected temperature x1 and a measurement temperature x2, an increment delta u of the heater power is controlled based on a set control method, so that the measured temperature x2 reaches an expected index; (2) a fuzzy controller is designed, input and output discourse domains and a membership degree function are determined and a fuzzy rule table is determined, ambiguity resolution is carried out to obtain a corresponding an increment delta u of the output heater power; (3), a PID controller is designed; and (4), a proper switching strategy is selected and switching between fuzzy control and PID control is carried out. According to the method disclosed by the invention, the adjustment time of the control system is shortened; the system stability can be improved; a temperature changing trend within a period of time can be predicted; and the system hysteresis quality can be reduced.