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发明公开
CN107050015A 卵南美菊素作为制备抗肺癌、肝癌和结肠癌药物中的应用 有权

卵南美菊素作为制备抗肺癌、肝癌和结肠癌药物中的应用
摘要：
本发明涉及医药技术领域，是一种卵南美菊素作为制备抗肺癌、肝癌和结肠癌药物中的应用；本发明首次提出了卵南美菊素对人肺癌细胞株A549、人肝癌细胞株BEL‑7402和人结肠癌细胞株HT‑29三种细胞株的生长均有不同程度的抑制作用；且卵南美菊素对人肝癌细胞株BEL‑7402和人结肠癌细胞株HT‑29两种细胞株的体外生长抑制作用明显优于阳性药TPT（盐酸拓扑替康），对人肺癌细胞株A549的体外生长抑制作用与阳性药TPT（盐酸拓扑替康）作用较为相近；说明卵南美菊素对体外肺癌细胞、肝癌细胞和结肠癌细胞具有明显的抗肿瘤作用，具有较好的药用前景。
摘要（英）：

The invention relates to the technical field of medicine, and discloses application of ovatifolin to preparation of lung cancer, liver cancer and colon cancer resisting drugs. The inhibiting effect of ovatifolin on the growth of a human lung cancer cell line A549, a human liver cancer cell line BEL-7402 and a human colon cancer cell line HT-29 is disclosed for the first time. The in-vitro growth inhibiting effect of ovatifolin on the human liver cancer cell line BEL-7402 and the human colon cancer cell line HT-29 is obviously higher than that of the positive drug TPT (topotecan hydrochloride). The in-vitro growth inhibiting effect of ovatifolin on the human lung cancer cell line A549 is close to that of the positive drug TPT (topotecan hydrochloride). Therefore, it is shown that ovatifolin has a remarkable anti-tumor effect on in-vitro lung cancer cells, liver cancer cells and colon cancer cells, and has broad medicinal prospects.

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