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发明公开
CN107050471A 基于富勒烯的靶向且具有快速清除特征的显像纳米探针及其制备方法和应用 无效 - 驳回

基于富勒烯的靶向且具有快速清除特征的显像纳米探针及其制备方法和应用
摘要：
本发明公开了基于富勒烯的靶向且具有快速清除特征的显像纳米探针及其制备方法和应用，该纳米探针为64Cu‑NOTA‑C60‑PEG‑cRGD，其中64Cu为正电子金属放射性核素，NOTA为双功能螯合剂p‑SCN‑Bn‑NOTA，C60为由60个碳原子构成的富勒烯，PEG为多臂‑聚乙二醇‑氨基，cRGD为特异性靶向整合素αvβ3的环状多肽Cyclo(Arg‑Gly‑Asp‑D‑Phe‑Cys)peptide。本发明纳米探针不仅能通过配体‑受体作用特异性地靶向整合素αvβ3高表达的肿瘤组织，还能通过PET成像进行实时、非侵入的监测，更具有在体内快速清除的安全特征，从而实现对癌症进行安全有效地诊断。
摘要（英）：

The invention discloses an imaging nano probe with a rapid clearance characteristic based on targeting of fullerene and a preparation method and application of the imaging nano probe. The nano probe is 64Cu-NOTA-C60-PEG-cRGD, wherein 64Cu is positron metal radionuclide; NOTA is a bifunctional chelator p-SCN-Bn-NOTA; C60 is fullerene formed by 60 carbon atoms; PEG is multi-arm-polyethylene glycol-amino; and cRGD is a cyclic polypeptide Cyclo (Arg-Gly-Asp-D-Phe-Cys) peptide for specifically targeting integrin alpha-v-beta3. The nano probe is capable of specifically targeting a high-expression tumor tissue of the integrin alpha-v-beta3 through ligand-receptor action and carrying out real-time non-invasive monitoring through PET imaging, and has a security feature of rapid clearance in vivo, thereby achieving safe and effective diagnosis of cancers.

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