The invention relates to a preparation method of a pH sensitive coaxial polylactic acid caprolactone (PLCL)/gelatin dual-drug-loading fiber scaffold. The preparation method comprises the following steps: dissolving gelatin and sodium bicarbonate in a solvent to obtain a shell layer solution; dissolving the PLCL in a solvent to obtain a core layer solution; adding an antibacterial drug and an anti-cancer drug into the solution respectively, stirring for dissolving to obtain a spinning liquid, performing coaxial electrostatic spinning, and drying to obtain the fiber scaffold. The preparation method has the advantages of adoption of normal temperature and normal pressure experimental conditions, simple preparation process, easiness in control, and low manufacturing cost.