The invention provides an earthquake data orthogonalized de-noising method. The earthquake data orthogonalized de-noising method comprises steps of 1) performing regular de-noising on earthquake data to obtain an effective estimation of a de-noised signal and an effective estimation of noise, 2) designing a time window according to a condition of noise, 3) performing orthogonalized calculation on the effective estimation of the signal and the effective estimation of the noise in the time window, and 4) using an orthogonalized factor to obtain a final de-noising result. The earthquake data orthogonalized de-noising method has a reliable effect and easy implantation, can directly use a de-noising result of a conventional method and can extract effective signals from a noise result and the noise of the signal result so as to obtain a final de-noising result, and greatly improves a de-noising effect. The de-noising effect is qualitative improved compared with the former effect through performing orthogonalization de-noising on the basis of a conventional de-noising result.