The invention discloses an intelligent vending machine which comprises an installation box, a storage box, a refrigerating mechanism, a storage box driving mechanism, a fixed box and a picking push mechanism. The picking push mechanism is provided with a manipulator capable of extending and retracting in the storage box. The fixed box is provided with a man and machine interaction device. The storage box is of a transparent cylinder structure with storage cells arranged therein in a layered way; the storage cells on the same layer are in same-interval distribution around the center of circle, namely the rotating center of the storage box. The picking push mechanism controls the manipulator to pick articles in the storage cells and to send the articles out under control action of the man and machine interaction device, so that automatic vending is completed. Since the storage cells are in layered arrangement and are particularly in same-interval distribution around the center of circle, namely the rotating center of the storage box, multiple storage cells for storing the articles are provided on the each layer, and different articles can be stored in different storage cells; accordingly the intelligent vending machine has high article storage capacity and is capable of storing a wide range of articles.