The invention provides a drive circuit and a liquid crystal display. The drive circuit comprises a display module, a scan line driving module, a data line driving module, a signal compensation module and a test pixel unit. The test pixel unit is used for receiving a scanning signal provided by the scan line driving module and a data signal provided by the data line driving module; and the signal compensation module is used for monitoring current flowing through the test pixel unit and generating a voltage compensation signal to the display module, wherein the voltage compensation signal, the scanning signal provided by the scan line driving module and the data signal provided by the data line driving module jointly drive the display module to display pictures. The drive circuit and the liquid crystal display improve the display effect of the liquid crystal display, are simple in structure and solve the technical problem that since an electronic device has the phenomenon of threshold voltage shift due to long-term use of an existing liquid crystal display, the display effect of the liquid crystal display is greatly influenced.