The present disclosure relates to thermal contrast therapy systems, and automated thermal contrast therapy devices configured to interact with such systems and to perform customized thermal contrast therapy treatment sequences. Treatments may be prescribed by a treatment provider or selected by a user of a thermal contrast therapy device associated with such a system. In some embodiments, a thermal contrast therapy device may be configured to receive an indication from one or more temperature sensors and/or flow meters and to effect a desired measure of heat transfer during treatment, for example, by automatically adjusting the temperature and/or flow rate of the heat transfer fluid. In some embodiments, a thermal contrast therapy device may be configured to receive an indication of one or more physiological parameter values and to perform a customized thermal contrast therapy treatment sequence based, at least in part, on the one or more physiological parameter values.