The invention relates to a technology for preparing a biopesticide by compounding bacillus cereus and antibiotic. The technology comprises the following steps of activating and culturing the bacillus cereus; inoculating the activate fluid into a fermenting culture medium in the same volume way, fermenting and culturing for 8 to 11h, and adding sugar and inorganic salt; fermenting and culturing for 20 to 25h, adding polyol, amino acid and antibiotic solutions, uniformly stirring, spraying and drying, so as to obtain the bacillus cereus live bacteria-antibiotic compound preparation. The technology has the advantages that the technology is simple, the production cycle is short, the operation is simple and convenient, the problem of low activity in the bacillus cereus biopesticide preparation produced by a conventional method is solved, the survival rate of bacteria and the bacteria inhibiting effect on crops are improved, the technology is suitable for large-batch production, and the application value is high.