The invention provides an antiskid and breathable men's leather shoe. The antiskid and breathable men's leather shoe comprises shoe sole and a vamp, wherein the shoe sole includes a front shoe sole and a rear shoe sole, the front shoe sole is provided with a plurality of through grooves along the width direction of the front shoe sole and provided with a plurality lines of air hole groups along the height direction of the front shoe sole, each air hole group comprises a plurality of air holes, and the air holes are communicated with the grooves; the vamp includes a front vamp, a middle vamp and a rear vamp, the front vamp is connected with the middle vamp through a single transverse strip, a plurality of first air holes are arranged in the middle vamp in a penetrating manner, the rear vamp is connected with the middle vamp through sewing, the front portion of the rear vamp is provided with a plurality of shoelace holes, a shoelace is arranged in the shoelace holes, the middle portion of the rear vamp is provided with a plurality of air holes groups, and each air hole group comprises a plurality of wave-shaped second air holes. The antiskid and breathable men's leather shoe is comfortable to wear, good in breathability, capable of effectively preventing bacterium breeding and quite attractive in appearance.