A comprehensive anti-seepage treatment method of a hamburger-type dike is characterized by comprising the following steps that firstly, measuring, pay-off and positioning are conducted along the trend of an anti-seepage wall, and the position of a grouting hole is determined; secondly, all pay-off holes are drilled to the set depth through a drilling machine, the drilling machine penetrates through a concrete layer to form pilot holes; thirdly, cement loess slurry is grouted repeatedly into every at least two pilot holes till slurry returning occurs; and fourthly, after solidified, the grouted pilot holes are subjected to high-pressure rotating spray construction along with the rest pilot holes, high-pressure rotating spray construction should be conducted every other hole, and hole openings of the pilot holes which are not constructed temporarily are blocked. After high-pressure rotating spray piles in the adjacent pilot holes are solidified, hole moving operation is conducted till high-pressure rotating spray construction of all the pilot holes is completed. All the high-pressure rotating spray piles on the same line form an anti-seepage wall. The comprehensive anti-seepage treatment method has the advantages that the construction speed is high, the period is short, and the influence of a construction field is little.