The invention discloses a gas pipeline fire prevention plug valve. The gas pipeline fire prevention plug valve comprises a main valve body with plug holes communicating with each other, a gas inlet and a gas outlet, and a rotary knob covering the upper end of the main valve body. A gas opening and closing mechanism used for opening and closing a gas passing channel from the gas inlet to the gas outlet is arranged at the inner side of the upper end of the main valve body. A thermosensitive device mounting hole used for mounting a thermosensitive device is further formed in one side of the upper plug hole of the main valve body. A rotating mechanism which makes the gas opening and closing mechanism close the gas passing channel from the gas inlet to the gas outlet under the driving action of heating motion of the thermosensitive device is arranged on the thermosensitive device mounting hole and located at the inner side of the upper end of the main valve body. A limiting pin with one end being inserted into the rotary knob and used for controlling the set rotating angle of the rotary knob is arranged at one side of the rotary knob. The gas inlet of the main valve body is internally and fixedly provided with a dust screen through a dust screen clamping spring. The gas pipeline fire prevention plug valve is reliable in structure, durable in use, and capable of achieving the dual functions and effectively preventing leakage of poisonous and inflammable gases when a fire breaks out.