The invention discloses a comprehensive evaluation method for a sweet spot earthquake of shale. The method comprises the following steps of 1), according to a geological evaluation requirement for exploiting a shale gas field, predicating gas content, pressure cracking property, porosity, stratum pressure and development conditions of crack and crustal stress of a shale gas layer by means of three-dimensional prestack time migration data and prestack gathering data, manufacturing a construction map and a depth map and analyzing a shale gas layer preserving condition, and obtaining a predication map for main parameters of quality of industrial area shale gas; 2), based on analysis for geological sweet spots and engineering sweet spots in shale gas layer exploitation, preferably selecting a main geophysical parameter which is related with exploitation, and determining a single-parameter threshold value; 3), endowing different weights according to contribution of each parameter in shale exploitation, and establishing a shale sweet spot earthquake comprehensive evaluation parameter list; and 4), performing weighting operation on a single parameter, obtaining a shale gas comprehensive evaluation value P, and performing comprehensive evaluation on a shale gas block according to the value of P. The evaluation result of the invention can be used for performing evaluation and classification of the shale gas layer, thereby guiding exploitation of the shale gas layer.