A micro-particle chrominance automatic clustering analysis system comprises a large-area color micro-particle plane image acquisition system and a micro-particle chrominance clustering counting system. The large-area color micro-particle plane image acquisition system comprises a large field-of-view microscopy system, and a large-target-surface camera. The large field-of-view microscopy system images large-area color particles on the image sensor of the large-target-surface camera. The large-target-surface camera converts an optical signal received by the image sensor into a computer image. The micro-particle chrominance clustering counting system subjects the computer image to micro-particle image segmentation and chrominance recognition, performs clustering statistics based on the chrominance of the micro-particles, and outputs statistical information of the large-area color micro particles for analysis.