The present invention provides an antenna structure. The antenna structure comprises a metal frame and a stub antenna. The metal frame is provided with an open groove and two break points. The two break points are respectively arranged at the two ends of the open groove and are vertical to the open groove. The metal frame is divided into a first portion and a second portion by the open groove and the two break points. The open groove and the two break points together enclose the first portion. The first portion forms the radiation body of the antenna structure and is and is grounded through the second portion. The stub antenna is arranged inside the metal frame and is arranged at an interval from the radiation body of the antenna structure. The radiation energy of the antenna structure is mainly concentrated on the upper half ball, so that the receiving and transmitting performance of the antenna structure is effectively improved. The invention also provides a wireless communication device with the antenna structure.