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发明公开
CN107109489A 纳米孔RNA表征方法 有权

纳米孔RNA表征方法
摘要：
本发明涉及通过随着目标RNA多核苷酸相对于跨膜孔移动，获取一个或多个测量值来表征目标RNA多核苷酸的新方法。通过DNA解旋酶控制该移动。本发明也涉及修饰的RNA构建体，其中所述RNA多核苷酸已被修饰以增强DNA解旋酶对其的结合。
摘要（英）：

The invention relates to a new method of characterising a target RNA polynucleotide by taking one or more measurements as the target RNA polynucleotide moves with respect to a transmembrane pore. The movement is controlled by a DNA helicase. The invention also relates to a modified RNA construct wherein the RNApolynucleotidehas been modified to increase DNA helicase binding thereto.

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