The invention provides a mandarin fish large-scale artificial selective breeding method, and relates to the technical field of mandarin fish breeding. In Anhui Province, aboriginal mandarin fish type resources are rich, the breeding modes are diversified, the breeding distribution is wide, the fry requirement quantity is large, and to develop Anhui aboriginal mandarin fish artificial selective breeding, key technologies of mandarin fish parent selection, cultivation, induced spawning and fry cultivation, disease prevention and control and the like are studied to promote the development of the mandarin fish industry. Through the adoption of the technologies, the mandarin fish survival rate can be increased, the survival rate reaches up to 80%, the fry bodies are rapid in growth, and can grow by 1cm every 3 d, the specification is neat, the vigor is high, the constitution is good, and fry can easily grow in large scale.