The invention discloses a toxic and odor gas purification treatment device. The device comprises a toxic and odor gas gathering mechanism, a waste heat recovery chamber, a catalytic oxidation chamber and a shell, the waste heat recovery chamber and the catalytic oxidation chamber are installed in the shell, the toxic and odor gas gathering mechanism is installed at an air inflow end outside the shell, the toxic odor gas gathering mechanism communicates with the waste heat recovery chamber, and the waste heat recovery chamber communicates with the catalytic oxidation chamber. The toxic and odor gas purification treatment device has high purification efficiency, thorough handling of toxic and odor gas, high recovery efficiency of waste heat, simple structure and reliable operation.