A goods case stabilizing device comprises a goods frame mounted in a bus, a case body used for storing goods and a goods frame door mounted at the front end of the goods frame. A cavity used for storing the case body is arranged in the goods frame. An open groove is formed in the top end in the rear portion of the case body. A sleeve ring is fixedly arranged in the open groove and fixedly provided with an elastic cord. The other end of the elastic cord is fixedly connected on the top wall of the cavity in the goods frame. A guide strip extending forward and backward is arranged at the midpoint of the bottom wall of the cavity. A guide groove matched with the guide strip is formed in the midpoint of the lower end face of the case body. A forward-backward sliding groove extending forward and backward is formed in the bottom wall of the cavity in a left and right equivalent mode. A pressing-pushing rod is slidably mounted in the forward-backward sliding groove. An up-down driving groove extending up and down and communicating with the forward-backward sliding groove and the cavity is formed in the bottom wall of the cavity in a left and right equivalent mode. A longitudinal locking arm is slidably mounted in the up-down driving groove.