Embodiments of the present invention provide a heterogeneous cluster system for CFD simulation calculation and a CFD calculation method. The heterogeneous cluster system for CFD simulation calculation comprises a central processing unit (CPU) and a hardware accelerator. The CPU is configured to divide the received CFD task into task blocks, according to the attribute of the CFD task, the CFD boundary condition and the performance parameter of the hardware accelerator, determine the hardware accelerator for calculating the task blocks, and transmit the task blocks to the hardware accelerator; and the hardware accelerator is configured to receive and calculate task blocks transmitted by the CPU and transmit the calculation result to the CPU. According to the technical scheme of the embodiments of the present invention, by constructing the heterogeneous cluster system integrating the CPU, the GPU and the FPGA, calculation resources are intelligently deployed according to the attribute of the CFD task, so that the bottleneck problem of CFD simulation calculation is solved and the running efficiency of the CFD application is improved.